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| 1415 |
| | | Sir William de Milbourne, the first known resident of Milbourne House, dies and is buried in the Barnes parish church of St Mary’s | |
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| 1467 |
| | | Sir John Saye, Chancellor of the Exchequer to Edward IV, becomes the first recorded resident of Barn Elms, the manor house of Barnes | |
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| c. 1485 |
| | | A tower is added to St Mary's in Barnes | |
|  | St Mary's Church, in Barnes
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| 1493 |
| | | John Williams, a brewer, acquires half an acre of land beside the Thames in Mortlake and builds on it a house subsequently known as Cromwell House | |
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| c. 1520 |
| | | Thomas Cromwell’s sister Katherine and her husband Morgan Williams move into the Mortlake house inherited from Morgan’s uncle John Williams | |
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| 1566 |
| | | The mathematician, astrologer and alchemist John Dee moves to a house in Mortlake on the site of the building now known as the Queen’s Head | |
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| 1571 |
| | | John Dee brings back from Lorraine a cartload of special instruments for alchemy, to be installed in his laboratory at Mortlake | |
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| 1579 |
| | | Queen Elizabeth buys the lease of Barn Elms for her spymaster, Sir Francis Walsingham | |
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| 1583 |
| | | John Dee sets off for six years of travel in Europe, during which his laboratory and library in Mortlake is plundered by former associates and rivals | |
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| 1619 |
| | | Dee’s house and estate are purchased by Francis Crane to establish the Mortlake Tapestry Works, with eighteen looms operated by Flemish weavers | |
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